Rule lifecycle · DOCKET:DEA-1143

Schedules of Controlled Substances: Placement of N-Desethyl Isotonitazene and N-Piperidinyl Etonitazene in Schedule I

Department of Justice, Drug Enforcement Administration — observed across 3 documents over 790 days. Use the source documents below before deciding whether this affects your business.

In plain English

The government adds two synthetic opioids, N-Desethyl Isotonitazene and N-Piperidinyl Etonitazene, to Schedule I, making them completely illegal to manufacture, distribute, or possess. If you make or sell chemicals or pharmaceuticals, audit your inventory and supplier agreements to ensure you're not handling these newly banned substances.

First seen

Oct 25, 2023

Last seen

Dec 23, 2025

Latest stage

Rule

PRORULE → RULE

790d

Effective on

Thursday, January 22, 2026

Stage timeline

  1. Proposed·Oct 25, 2023

    N N Schedules of Controlled Substances: Temporary Placement of-Desethyl Isotonitazene and-Piperidinyl Etonitazene in Schedule I

    #2023-23379

  2. Final·Jul 29, 2024

    Schedules of Controlled Substances: Temporary Placement of N-Desethyl Isotonitazene and N-Piperidinyl Etonitazene in Schedule I

    effective Jul 29, 2024#2024-16391

  3. Final·Dec 23, 2025

    Schedules of Controlled Substances: Placement of N-Desethyl Isotonitazene and N-Piperidinyl Etonitazene in Schedule I

    effective Jan 22, 2026#2025-23717