Rule lifecycle · DOCKET:DEA-1494

Schedules of Controlled Substances: Temporary Placement of Ethyleneoxynitazene, Methylenedioxynitazene, 5-Methyl Etodesnitazene, N-Desethyl Etonitazene, N-Desethyl Protonitazene, N,N-Dimethylamino Etonitazene, and N-Pyrrolidino Isotonitazene in Schedule I

Department of Justice, Drug Enforcement Administration — observed across 2 documents over 111 days. Use the source documents below before deciding whether this affects your business.

In plain English

DEA schedules seven synthetic opioids (nitazenes, variants) Schedule I—bans manufacture, distribution, possession without federal license. Business handles chemicals: verify inventory excludes these substances, update compliance docs now.

First seen

Jun 26, 2025

Last seen

Oct 15, 2025

Latest stage

Rule

PRORULE → RULE

111d

Effective on

Wednesday, October 15, 2025

Stage timeline

  1. Proposed·Jun 26, 2025

    Schedules of Controlled Substances: Temporary Placement of Seven Benzimidazole-Opioids in Schedule I

    #2025-11462

  2. Final·Oct 15, 2025

    Schedules of Controlled Substances: Temporary Placement of Ethyleneoxynitazene, Methylenedioxynitazene, 5-Methyl Etodesnitazene, N-Desethyl Etonitazene, N-Desethyl Protonitazene, N,N-Dimethylamino Etonitazene, and N-Pyrrolidino Isotonitazene in Schedule I

    effective Oct 15, 2025#2025-19542