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The Small Business
Rule Change Brief

Vol. 1 · No. 1084

Monday, August 24, 2026

1084 issues in archive

Rule lifecycle · DOCKET:Docket No. DEA-1641

Schedules of Controlled Substances: Temporary Placement of O-Desmethyltramadol in Schedule I

Justice Department, Drug Enforcement Administration — observed across 2 documents over 49 days. Use the source documents below before deciding whether this affects your business.

In plain English

Temporarily, the federal government is placing O-Desmethyltramadol, a substance related to the painkiller tramadol, into the most restricted drug category, making it illegal to make, sell, or own. Check your inventory if you make or sell supplements or chemicals, and immediately stop any sales or possession of this substance.

First seen

Jun 24, 2026

Last seen

Aug 12, 2026

Latest stage

Rule

PRORULE → RULE

Effective on

Wednesday, August 12, 2026

Stage timeline

  1. Final·Jun 24, 2026·91 FR 37822

    Schedules of Controlled Substances: Temporary Placement of O-Desmethyltramadol in Schedule I

    #2026-12654

  2. Final·Aug 12, 2026·91 FR 52013

    Schedules of Controlled Substances: Temporary Placement of O-Desmethyltramadol in Schedule I

    effective Aug 12, 2026#2026-16413